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Research Paper | Dental Science | Indonesia | Volume 8 Issue 1, January 2019 | Popularity: 6.9 / 10

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Comparison of the Effect of the Application of Jatropha Curcas Linn Sap Gel with Gelatinsponge on Fibrin Density after Tooth Extraction in Sparague Dawley Mice

Hadira, Hardianto Andri, Kasim Awin, Harlina Eva, Syamsudin Endang

Abstract: The bleeding during and after tooth extraction requiring local haemostatic agent administration is bleeding due to capillary or arteriolar trauma to the tooth socket. The most commonly used local haemostatic drug is gelatin sponge derived from animal gelatin, which is porous, flexible, easy to absorb, non-oxygenic, non-allergic, stimulates the formation of blood coagulation and clogs the bleeding area. According to the WHO in 2013, 80% of the world's population still relies on traditional medicines which are mostly based on plants. J. c Linn castor plants contain flavonoids, and tannins which can accelerate the process of cessation of bleeding and formation of blood clots. The study was conducted to analyze the differences in the effect of J. c Linn castor gel application with gelatin sponge on fibrin density and blood clotting time. This study was a pure experimental study in 27 S. dawley mice which were randomly divided into 3 groups. Group 1 was the control, Group 2 was applied Jc Linn castor gel and Group 3 was applied gelatin sponge after tooth extraction. The clotting time was calculated and, after 5 minutes, nefrocted. Histological preparations were made with Hematoxylin-eosin staining, then the fibrin density was assessed under a microscope. Data was analyzed with non parametric kruskal wallis and one way Anova. The results of the kruskal wallis test obtained a p-value of 0.072 (p> 0.05) which means that there was no significant difference in fibrin density between the groups using Jc Linn castor gel and gelatin sponge gel. From the results of the oneway ANOVA test, p-values were obtained at 0, 000 (p

Keywords: blood clot, fibrin, Jc Linn castor gel

Edition: Volume 8 Issue 1, January 2019

Pages: 1087 - 1091

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