Expression of HER2 and BRCA1 in Breast Tumors among Sudanese Women, Immunohistochemical Study

Mohamed Ahmed Mohamed Osman, Saadalnour Abusail Mustafa, Ihab Hamed Nourein Hamed, Faris Merghani Eltom, Shawgi Abdelrhman Elsiddig, Rabab Ali Alhag

Abstract: Objective: The aim of this study was to detect HER2/ Neu and BRCA1 expression in breast cancer using immunohistochemical methods. Methodology: A retrospective descriptive study was performed on 50 samples from patients diagnosed with breast cancer as well as 50 from benign breast tumors. HER/neu and BRCA1 expression was assessed using immunohistochemistry (IHC). Result: HER/neu was expressed in 4/50 (8 %) of breast cancer and 11/50 (22 %) of benign breast tumors whereas BRCA1 was expressed in 9/50 (18 %) of breast cancers and 7/50 (14 %) of benign breast tumors, with significance at p values of 0.045 and 0.393 respectively. Conclusions: There is insignificant association between HER/neu and BRCA1 expression and breast cancers among Sudanese patients.

Keywords: Breast cancers- Sudanese- HER/neu- BRCA