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Research Paper | Histopathology | Saudi Arabia | Volume 8 Issue 1, January 2019
Expression of HER2 and BRCA1 in Breast Tumors among Sudanese Women, Immunohistochemical Study
Mohamed Ahmed Mohamed Osman | Saadalnour Abusail Mustafa | Ihab Hamed Nourein Hamed | Faris Merghani Eltom  | Shawgi Abdelrhman Elsiddig | Rabab Ali Alhag
Abstract: Objective: The aim of this study was to detect HER2/ Neu and BRCA1 expression in breast cancer using immunohistochemical methods. Methodology: A retrospective descriptive study was performed on 50 samples from patients diagnosed with breast cancer as well as 50 from benign breast tumors. HER/neu and BRCA1 expression was assessed using immunohistochemistry (IHC). Result: HER/neu was expressed in 4/50 (8 %) of breast cancer and 11/50 (22 %) of benign breast tumors whereas BRCA1 was expressed in 9/50 (18 %) of breast cancers and 7/50 (14 %) of benign breast tumors, with significance at p values of 0.045 and 0.393 respectively. Conclusions: There is insignificant association between HER/neu and BRCA1 expression and breast cancers among Sudanese patients.
Keywords: Breast cancers- Sudanese- HER/neu- BRCA
Edition: Volume 8 Issue 1, January 2019,
Pages: 323 - 327