International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064

Downloads: 146 | Views: 218 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper | Medicine Science | India | Volume 7 Issue 4, April 2018

Predictors of Morbidity and Mortality in Organophosphorous Compound Poisoning at a Tertiary Care Hospital in Karnataka

Dr Ashray V [2] | Dr Narendra S S | Dr Vijay Kumar [3] | Dr Sachin Nayak Sujir [2]

Abstract: Background Poisoning is a significant global public health problem. According to World Health Organisation, in 2012 an estimated 1, 93, 460 people died worldwide from unintentional poisoning causing a loss of over 10.7 million DALYs (disability adjusted life years). In India, organophosphorous (OP) poisonings form a majority of acute poisoning cases in rural and sub urban areas. Material and Methods A total of 65 patients admitted above the age of 18 years, with a history of ingestion or inhalation of organophosphorus compounds were included in the study. Data were presented either as mean standard deviation (SD) or as percentages. Probability values of P < 0.05 were taken as significant. Results 44 (67.7 %) were males and 21 (32.3 %) were females. Over half of the patients, thirty three in number (50.76 %), were young adults in the age group of 21-33 years. Majority i. e.30 (46.2 %) presented to the hospital 2-4 hrs after consumption. (41.5 %) of the patients required mechanical ventilation with a mean duration of 3.55 + 2.72 (n+SD) days among whom 15 (23.07 %) required ventilation for < 4 days and 12 (18.46 %) required ventilation for > 4 days respectively. A significant correlation (p=0.023) was found between lower serum pseudocholinesterase levels (8 days). A significantly lower mean s. pseudocholinesterase level of 605.33 IU was found in those who died as compared to 2699.91 IU among those who survived (p=0.042). Conclusion Serum pseudocholinesterase levels can guide decision making with regard to need of intensive care management and can aid in predicting duration of intensive care needed and hospital stay.

Keywords: Organophosphorous poisoning, serum pseudocholinesterase, morbidity, mortality, intensive care unit

Edition: Volume 7 Issue 4, April 2018,

Pages: 759 - 761

How to Download this Article?

Type Your Valid Email Address below to Receive the Article PDF Link

Verification Code will appear in 2 Seconds ... Wait