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M.Tech / M.E / PhD Thesis | Biology | Malaysia | Volume 6 Issue 2, February 2017
Evaluation of A Novel Formulation from Functional Foods for Hypoglycemic and Weight Loss Activities in High-Fat Balb/C Mice
Hun Alhasin Salem | Moklesur Rahman Sarker 
Abstract: Diabetes is a metabolic disorder in which the body does not produce enough insulin to regulate blood glucose levels or where the insulin produced is unable to work efficiently. There are two main types of diabetes Type 1 and Type 2 diabetes. Obesity is only associated with type 2 diabetes. Diabetes mellitus and obesity has the relationship since many years and it is most prevalent despite intense research. Functional foods have a potentially positive effect and help reduce the risk of diseases on health beyond basic nutrition. Our present study aimed to develop a new formulation from functional foods (FFF) and to evaluate its therapeutic potential for the effective management of diabetes and obesity avoiding major adverse effects in animal model. Obesity was induced to Balb /c mice with high fat diet for four weeks. The mice were treated with the formulation of functional foods (FFF) at the doses of 200, 400 and 600 mg/kg and metformin (200 mg/kg) orally. The glucose levels were measured 2 hours, 3 hours, 2 weeks and body weight was measured after 2 weeks of treatment with the formulation. Treatment of 200 mg/kg Metformin shows significant reduction at 3 hours, 2 hours and 2 weeks, FFF treatment of 200 mg/kg shows promising results at 3 hours, 2 hours on 2nd day, FFF treatment of 400 mg/kg signify decrease in glucose level at 2 hours of 3rd day and 2 weeks and FFF treatment of 600 mg/kg produce significant reduction at 3 hours and 2nd week. The body weight results of at all the 4 treatment was found to be expressively reduced. All the data compared to that of the positive and negative control (untreated) were done using the Students t-test at P < 0.05. The formulation of function foods significantly reduced the post-prandial plasma glucose and enhanced weight loss in HFD Balb/c mice. Taken together, this study determined the present formulation of functional foods, which might be recommended for the prevention and treatment of obesity and diabetes.
Keywords: Diabetes Multiuse, Hypoglycemia, Functional foods, High fat diet, Obesity, Nutraceuticals
Edition: Volume 6 Issue 2, February 2017,
Pages: 1020 - 1027