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Research Paper | Biochemistry Science | India | Volume 5 Issue 9, September 2016

Microalbuminuria and Hyperinsulinemia as Predictors of Cardiovascular Disease in Metabolic Syndrome Patients

Anupa Prasad | Sudhanshu Shekhar | K. K. Sinha | Tannu Kumari

Abstract: Introduction Metabolic syndrome is a cluster of metabolic factors which includes central obesity, insulin resistance, dyslipidemia, and hypertension. Microalbuminuria has also been considered to be a component of metabolic syndrome. It is associated with a two fold increase in cardiovascular diseases and 1.5 fold rises in all cause mortality. Microalbuminuria has an ability to predict cardiovascular disease mortality as it is a marker for endothelial injury. Materials and Methods A cross sectional study was performed including 250 subjects aged between 18-60 years in a state of fasting for atleast 10 hours. Fasting insulin, fasting blood sugar, lipid profile and urinary microalbumin creatinine ratio (ACR) measurement were done in metabolic syndrome patients. Independent t test and chi square test were done to analyze the data. A p value <0.05 was considered statistically significant Results Hyperinsulinemia was found to be strongly and significantly associated with microalbuminuria and urinary microalbumin creatinine ratio (p value < 0.0001). There was a strong and highly significant correlation between insulin and urinary ACR. Microalbuminuria was also found to be significantly associated with diastolic blood pressure (p= 0.021) and systolic BP (p=0.016). Conclusion Microalbuminuria has been reported to be a good cardiovascular marker by many research workers. In our cross sectional study, a strong and significant association has been observed between hyperinsulinemia and microalbuminuria. Hence hyperinsulinemia and microalbuminuria predict probability of developing cardiovascular disease and there is a need for developing guidelines for their management to decrease the global burden of cardiovascular diseases.

Keywords: Metabolic Syndrome, Hyperinsulinemia, Microalbumin Creatinine Ratio, Microalbuminuria, Cardiovascular Disease

Edition: Volume 5 Issue 9, September 2016,

Pages: 291 - 295