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Research Paper | Chemistry | Iraq | Volume 4 Issue 9, September 2015
Synthesis and Biological Evaluation of a mutual Prodrug of Mafenide and Nalidixic Acid by Amino Acid Spacer
Enas Sami Ali | Ahlam J. Qasir [2]
Abstract: The aim of this study has been to synthesize a useful drug, which may act with effectiveness both on the gram-positive and gram-negative bacteria (broad-spectrum). An amide-based mutual pro drugs were synthesized by coupling Mafenide acetate with Nalidixic acid by amino acid spacer (glycine or phenylalanine), and evaluated for in-vitro antibacterial activity with significant results.
Keywords: Nalidixic acid, Mafenide acetate, Pro drug, Antibacterial, glycine and phenylalanine
Edition: Volume 4 Issue 9, September 2015,
Pages: 992 - 995
Similar Articles with Keyword 'Antibacterial'
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Research Paper, Chemistry, United Kingdom, Volume 4 Issue 1, January 2015
Pages: 1527 - 1529Antibacterial Studies of Leucine Complexes of Fe (III) and Cu (II)
K. Asemave [3] | B. A. Anhwange | T. J. Anom
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Research Paper, Chemistry, India, Volume 11 Issue 1, January 2022
Pages: 1319 - 1324Design, Molecular Docking, DFT and Antimicrobial Studies of Novel Benzimdazole Derivatives
A. Adhilakshmi | S. Darlin Quine