Synthesis and Biological Evaluation of a mutual Prodrug of Mafenide and Nalidixic Acid by Amino Acid Spacer
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064

Research Paper | Chemistry | Iraq | Volume 4 Issue 9, September 2015

Synthesis and Biological Evaluation of a mutual Prodrug of Mafenide and Nalidixic Acid by Amino Acid Spacer

Enas Sami Ali, Ahlam J. Qasir

The aim of this study has been to synthesize a useful drug, which may act with effectiveness both on the gram-positive and gram-negative bacteria (broad-spectrum). An amide-based mutual pro drugs were synthesized by coupling Mafenide acetate with Nalidixic acid by amino acid spacer (glycine or phenylalanine), and evaluated for in-vitro antibacterial activity with significant results.

Keywords: Nalidixic acid, Mafenide acetate, Pro drug, Antibacterial, glycine and phenylalanine

Edition: Volume 4 Issue 9, September 2015

Pages: 992 - 995

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How to Cite this Article?

Enas Sami Ali, Ahlam J. Qasir, "Synthesis and Biological Evaluation of a mutual Prodrug of Mafenide and Nalidixic Acid by Amino Acid Spacer", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=SUB158208, Volume 4 Issue 9, September 2015, 992 - 995

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