Low Grade Chondrosarcoma on FNAC: A Diagnostic Dilemma

Abstract: Chondrosarcomas are malignant tumors of cartilaginous origin & is the 2nd most common primary malignant tumor of bone. It usually occurs in Lower extremities & pelvis & after 4th decade of life. Its incidence in the 1st & 2nd decade of life is only 3.8 %. A 28 years old male patient presented with a Large swelling measuring (7 x 6cms) on the chest wall (right side). Chest Xray & CT scan showed cortex and soft tissue masses. FNAC of the Chest lesion shows Chondromyxoid Stroma, Chondroid fragments & benign Chondrocytes. A diagnosis of Low Grade Chondrosarcoma was made. HPR Showed Spindle shaped Cells arranged in Storiform pattern. The cells Shows marked Pleomorphism, Nuclear atypia, Hyperchromasia, Mitosis & Tumour giant cells (MFH Pattern). A Diagnosis of De-Differentiated Chondrosarcoma was made. Chondrosarcoma on Thorax/chest wall in a 28 year old patient is very rare in terms of Age & location. Also cytological differentiation between Enchondroma, Low Grade Chondrosarcoma & High Grade Chondrosarcoma is very difficult. Clinico-Radiological and Pathological correlation is essential in Reporting Bone and Soft tissue tumours. THE VERY RARE NATURE OF THIS DISEASE MERITS ITS REPORTING

Keywords: FNAC, MFH, Pleomorphism, De-Differentiated Chondrosarcoma, Enchondroma

Edition: Volume 4 Issue 6, June 2015,

Pages: 121 - 123