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Informative Article | Health and Medical Sciences | Volume 15 Issue 7, July 2026 | Pages: 226 - 228 | India
Effect of Different Doses of Ondansetron on Hemodynamic Status in Patients Undergoing Elective Caesarean Section Under Spinal Anaesthesia: A Randomized Controlled Trial
Abstract: Background: Spinal anaesthesia for elective caesarean section is associated with hypotension (incidence up to 80%), bradycardia, nausea-vomiting, and shivering. Ondansetron, a 5-HT3 receptor antagonist, attenuates the Bezold-Jarisch reflex and may reduce these complications. This study compares prophylactic ondansetron 4 mg (O4) vs 6 mg (O6) vs normal saline (control) on haemodynamic parameters and complication rates. Methods: A prospective, double-blind, randomized controlled trial was conducted at PannaDhai Zanana Hospital, RNT Medical College, Udaipur from April 2022 to June 2022. 150 ASA I-II pregnant females undergoing elective caesarean section were randomized equally into three groups (n=50 each). The intervention was administered IV 20 minutes before spinal anaesthesia. Primary outcome: MAP changes. Secondary outcomes: hypotension incidence, vasopressor requirement, bradycardia, shivering, nausea-vomiting. Results: Baseline demographics were comparable. Mean SBP and MAP were significantly higher in O4 and O6 groups vs control at 6, 8, 10, and 12 minutes (p<0.05). Hypotension incidence: Control 40%, O4 16%, O6 14% (p<0.05). Vasopressor requirement: Control 38%, O4 12%, O6 10% (p<0.05). Bradycardia: Control 24%, O4 10%, O6 8%. Shivering: Control 38%, O4 4%, O6 4%. Nausea-vomiting: Control 42%, O4 8%, O6 6%. No significant difference between O4 and O6 for any parameter (p>0.05). Conclusion: Prophylactic ondansetron (4 mg or 6 mg IV) significantly reduces hypotension, bradycardia, shivering, and nausea-vomiting after spinal anaesthesia for caesarean section. No significant difference exists between 4 mg and 6 mg doses; hence ondansetron 4 mg is recommended as the optimal prophylactic dose.
Keywords: Ondansetron, Spinal Anaesthesia, Caesarean Section, Hypotension, Bezold-Jarisch Reflex, Haemodynamic Stability
How to Cite?: Dr. Sarita Kumawat, Dr. Chandra Prakash Sharma, Dr. Suresh Kumar Kumawat, Dr. Devender Verma, "Effect of Different Doses of Ondansetron on Hemodynamic Status in Patients Undergoing Elective Caesarean Section Under Spinal Anaesthesia: A Randomized Controlled Trial", Volume 15 Issue 7, July 2026, International Journal of Science and Research (IJSR), Pages: 226-228, https://www.ijsr.net/getabstract.php?paperid=SR26702094945, DOI: https://dx.doi.org/10.21275/SR26702094945