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Case Report | Medical Science | Volume 15 Issue 7, July 2026 | Pages: 175 - 179 | India
Study of Serum Sodium and Serum Potassium in Acute Exacerbation of Chronic Obstructive Pulmonary Disease and their Correlation with Clinical Outcomes
Abstract: Objectives: To assess serum sodium and serum potassium levels in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and to evaluate the clinical outcomes. Methods: A prospective observational study was conducted at Sri Siddhartha Medical College Hospital, Tumakuru, over 18 months from March 2024 to September 2025. Sixty-six patients with AECOPD were included using purposive sampling. Clinical evaluation was performed using the Modified Medical Research Council (mMRC) dyspnea scale, and venous blood samples were analyzed with an electrolyte analyzer. Data were statistically evaluated using descriptive statistics and chi-square testing (p < 0.05). Results: The mean age of participants was 61.35 ± 6.17 years, with males comprising 75.8% of the cohort. Hyponatremia was present in 34.8% of patients (mean sodium 135.45 ± 3.21 mmol/L), while hypokalemia occurred in 25.8% (mean potassium 4.12 ± 0.65 mmol/L). Overall, 45.5% improved, 37.9% remained stable, and 16.7% were unchanged. A highly significant association was observed between potassium status and clinical outcomes (χ2 = 30.57, p < 0.001), whereas sodium demonstrated only a trend toward association. Conclusion: Electrolyte abnormalities are common among hospitalized AECOPD patients, and hypokalemia is strongly associated with poorer clinical outcomes. Routine electrolyte assessment and early correction, particularly of potassium imbalance, are important for improving recovery and guiding inpatient management.
Keywords: Acute exacerbation of COPD, serum sodium, serum potassium, hyponatremia, hypokalemia
How to Cite?: Dr. Gummadi Venkata Hemanth, Dr. Sharath Kumar D Shah, "Study of Serum Sodium and Serum Potassium in Acute Exacerbation of Chronic Obstructive Pulmonary Disease and their Correlation with Clinical Outcomes", Volume 15 Issue 7, July 2026, International Journal of Science and Research (IJSR), Pages: 175-179, https://www.ijsr.net/getabstract.php?paperid=SR26701221949, DOI: https://dx.doi.org/10.21275/SR26701221949