Formulation and Evaluation of Fluconazole Loaded Transferosomal Gel to Enhance Drug Delivery

D. T. Lakshmi Prabha, J. Ajis Vinoliya, V. Bavadharani, R. Naveen Kumar, H. Gayathri

Abstract: The formulation and evaluation of fluconazole-loaded transferosomal gel aim to enhance the drug's transdermal delivery by using transferosomes as carriers. Fluconazole, a widely used antifungal agent, often faces challenges like poor bioavailability when administered via conventional methods. Transferosomes, which are ultra-deformable vesicles composed of phospholipids, improve the permeability of the drug through the skin. The study involved the preparation of transferosomal vesicles encapsulating fluconazole using thin-film hydration techniques, followed by their incorporation into a gel matrix for easy application. The transferosomes' size, zeta potential, entrapment efficiency, and in vitro release profiles were characterized. The optimized transferosomal gel demonstrated enhanced skin penetration, prolonged drug release, and improved antifungal activity compared to conventional formulations. The gel system offers a promising approach for localized and controlled delivery of fluconazole, with potential applications in treating superficial fungal infections.

Keywords: Fluconazole, transferosomes, transdermal drug delivery, gel formulation phospholipids, skin penetration

How to Cite?: D. T. Lakshmi Prabha, J. Ajis Vinoliya, V. Bavadharani, R. Naveen Kumar, H. Gayathri, "Formulation and Evaluation of Fluconazole Loaded Transferosomal Gel to Enhance Drug Delivery", Volume 15 Issue 6, June 2026, International Journal of Science and Research (IJSR), Pages: 1450-1457, https://www.ijsr.net/getabstract.php?paperid=SR26626100917, DOI: https://dx.doi.org/10.21275/SR26626100917

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