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Case Report | Biomedical Sciences | Volume 15 Issue 6, June 2026 | Pages: 1356 - 1361 | India
Accelerated Chronic Wound Healing Through Percussive Oxygen Flow and Continuous Oxygen Changes in a Pressurized Chamber
Abstract: Diabetic foot ulcers and gangrenous wounds remain a major clinical challenge due to impaired perfusion, tissue hypoxia, infection, and delayed healing. Even after surgical intervention such as amputation, residual wounds often show poor granulation and prolonged healing because of compromised microcirculation and reduced local oxygen availability. This abstract presents a novel wound healing approach using continuous oxygen changes within a pressurized chamber, applied in the post-amputation setting for diabetic foot gangrene. Unlike intermittent or static oxygen delivery methods, this system provides a continuous flow of oxygen with controlled pressurization, enabling constant renewal of oxygen concentration at the wound interface and these changes help overcome diffusion limitations commonly seen in diabetic and ischemic tissues. This dynamic oxygen environment enhances diffusion into hypoxic tissues, maintains a favorable wound pO? gradient, and supports key physiological processes including angiogenesis, fibroblast proliferation, collagen synthesis, and bacterial load reduction. The pressurized chamber further enhances oxygen penetration into wound tissues while helping to reduce edema and bacterial burden. We report the case of a 54 year old male with type 2 diabetes mellitus who developed ischemic diabetic foot gangrene involving the first toe. Following surgical amputation, a pressurized chamber delivering percussive oxygen flow with continuous oxygen changes was applied to the wound site to accelerate granulation tissue formation, enhance wound bed preparation, and minimize the risk of secondary infection and delayed closure. The continuous flow of oxygen under controlled pressurization enables constant renewal of oxygen concentration at the wound interface, thereby addressing one of the major pathophysiological challenges in diabetic wound healing- chronic tissue hypoxia. This novel continuous oxygen therapy represents a promising adjunctive treatment for complex diabetic foot ulcers and post amputation wounds, with the potential to improve healing outcomes, reduce complications, and shorten overall recovery time.
Keywords: Diabetic foot ulcer, Topical oxygen therapy, Pressurised oxygen chamber, Tissue oxygenation, wound healing
How to Cite?: Dr. Soumya John, Sifi K P, Jaise Jacob, Safeer Kadavan, "Accelerated Chronic Wound Healing Through Percussive Oxygen Flow and Continuous Oxygen Changes in a Pressurized Chamber", Volume 15 Issue 6, June 2026, International Journal of Science and Research (IJSR), Pages: 1356-1361, https://www.ijsr.net/getabstract.php?paperid=SR26624145700, DOI: https://dx.doi.org/10.21275/SR26624145700