Studies on the Acetyl Cholinesterase Activity in Hamsters (Mesocricetus Auratus) Infected with Ancylostoma Ceylanicum
Abstract: Helminthic infections are among the most prevalent parasitic diseases, primarily found in tropical and subtropical areas. These infections are characterized by an endoparasitic hookworm affecting the intestinal region of the host. Reports of hookworm infections have been reported in many laboratory animals. The hookworm has a distinctive hook-like structure at its anterior end, which draws out nutrients from the host. Hookworm infections lead to metabolic disorders and significant disturbances in tissue structure and function. Acetyl cholinesterase, an enzyme related to the nervous system, plays a vital role in the hydrolysis of acetylcholine into acetic acid and choline. In the current study, the hookworm Ancylostoma ceylanicum was experimentally introduced into the host, Mesocricetus auratus. The infected host was subsequently examined by measuring the acetylcholinesterase levels in various tissues. The acetylcholinesterase content in M. auratus was analyzed biochemically in both infected and control samples. The biochemical estimation of acetylcholinesterase levels in the hamsters revealed that its activity was significantly higher in the brain, muscle, spleen, and lung tissues, adversely affecting muscular and neuronal functions. The concentration of acetylcholinesterase in the host tissues of M. auratus can provide insights into the pathogenicity of the A. ceylanicum infection. This paper explicates the levels of acetylcholinesterase in infected hamster and reveals its significance in the field of enzyme biochemistry.
Keywords: Acetylcholinesterase, Ancylostoma ceylanicum, Mesocricetus auratus, pathogenicity, enzyme biochemistry
How to Cite?: Rajani P. S., "Studies on the Acetyl Cholinesterase Activity in Hamsters (Mesocricetus Auratus) Infected with Ancylostoma Ceylanicum", Volume 15 Issue 6, June 2026, International Journal of Science and Research (IJSR), Pages: 1197-1201, https://www.ijsr.net/getabstract.php?paperid=SR26619121505, DOI: https://dx.doi.org/10.21275/SR26619121505