Downloads: 1
Original Research | Pathology | Volume 15 Issue 5, May 2026 | Pages: 1090 - 1094 | India
Morphologic Spectrum of BCOR-Expressing Sarcomas: Clinicopathologic Study of 37 Cases
Abstract: Introduction: BCOR (BCL6 co-repressor) sarcomas are a group of undifferentiated small round to spindle cell sarcomas harbouring the BCOR gene rearrangement, which share morphology with other mesenchymal and malignant round blue cell tumours. Aims & Objectives: To study the various morphologic patterns of BCOR-expressing sarcomas in bone and soft tissues. Methods: We collected 37 BCOR-positive cases over a 1-year period for detailed clinical profiles, morphology, and immunohistochemical analysis. Results: Twenty-one (56.7%) cases occurred in males and sixteen (43.2%) in females; the common age group being 11-20 years. The most common site involved was deep soft tissue. Visceral site involvement was seen in three cases. Histopathology predominantly showed spindled cell morphology. BCOR expression is a defining feature of BCS. The other markers frequently expressed alongside BCOR in BCS tumours are TLE1 (56.7%), MIC2 (56.7%), SATB2 (40.5%), NKX2.2 (5.4%), and WT1 (2.7%). Conclusion: We studied 37 cases of BCOR-expressing tumours in bone and soft tissues, highlighting the morphologic and immunohistochemical overlap. It is important to diagnose BCOR sarcomas as it has good prognosis than others, and there is emerging evidence of targeted therapies associated with it.
Keywords: BCOR, bone and soft tissue, morphologic spectrum, sarcoma
How to Cite?: Dr. Bhanita Baro, Dr. Shilpa Prabhudesai, "Morphologic Spectrum of BCOR-Expressing Sarcomas: Clinicopathologic Study of 37 Cases", Volume 15 Issue 5, May 2026, International Journal of Science and Research (IJSR), Pages: 1090-1094, https://www.ijsr.net/getabstract.php?paperid=SR26517224524, DOI: https://dx.dx.doi.org/10.21275/SR26517224524