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Analysis Study Research Paper | Neurology | Volume 15 Issue 3, March 2026 | Pages: 1721 - 1723 | Bulgaria
Association Between Type 2 Diabetes Mellitus, Cerebral Small Vessel Disease, and Cognitive Impairment: A Cross Sectional Study
Abstract: Background: Type 2 diabetes mellitus and cerebral small vessel disease are common in the elderly and are associated with cognitive impairment. Purpose: This study aimed to evaluate the independent and combined effects of diabetes mellitus and small vessel disease on cognitive function. Methods: A total of 190 participants were divided into four groups based on the presence or absence of diabetes mellitus and small vessel disease. Cognitive performance was assessed using standardized neuropsychological tests including MMSE, MOCA, memory tests, and processing speed measures. Statistical analysis was conducted at a 95% confidence level (p < 0.05). Results: Patients with both diabetes mellitus and small vessel disease demonstrated the poorest cognitive performance, particularly in global cognition, short term memory, delayed recall, attention, and processing speed. Both conditions were independently associated with cognitive impairment, while patients with either condition alone showed comparable cognitive profiles. Conclusions: Diabetes mellitus and small vessel disease independently contribute to cognitive impairment, supporting the hypothesis that early functional vascular dysfunction plays a role in diabetes related cognitive decline.
Keywords: vascular cognitive impairment, cerebral microangiopathy, neuropsychological assessment, executive function, type 2 diabetes mellitus
How to Cite?: Mirena Valkova, "Association Between Type 2 Diabetes Mellitus, Cerebral Small Vessel Disease, and Cognitive Impairment: A Cross Sectional Study", Volume 15 Issue 3, March 2026, International Journal of Science and Research (IJSR), Pages: 1721-1723, https://www.ijsr.net/getabstract.php?paperid=SR26327093409, DOI: https://dx.dx.doi.org/10.21275/SR26327093409