Gingival Sulcular Fluid as a Diagnostic Medium in Periodontal Health and Diseases: A Contemporary Review
Abstract: Gingival sulcular fluid (GSF) is a biologically active fluid located in the gingival sulcus that serves as a critical indicator of periodontal health and disease. Its composition reflects ongoing host?microbial interactions and inflammatory responses within periodontal tissues. This article provides a comprehensive and original review of GSF, focusing on its origin, composition, methodology of collection, and clinical applications. A structured methodology was employed to analyze existing literature on GSF biomarkers and their clinical implications. Findings indicate that GSF contains a wide range of cellular and molecular components, including cytokines, enzymes, and microbial products, which significantly increase during periodontal inflammation. The discussion highlights the importance of GSF in early diagnosis, disease monitoring, and evaluation of therapeutic outcomes. Despite certain methodological limitations, GSF remains a promising non-invasive diagnostic tool. Future advancements in molecular diagnostics are expected to enhance its role in precision-based periodontal care.
Keywords: Gingival sulcular fluid, periodontal disease, periodontal biomarkers, inflammation, crevicular fluid, diagnostics
How to Cite?: Dr. Ramandeep Singh, Dr. Simarjot Kaur, "Gingival Sulcular Fluid as a Diagnostic Medium in Periodontal Health and Diseases: A Contemporary Review", Volume 15 Issue 3, March 2026, International Journal of Science and Research (IJSR), Pages: 1658-1659, https://www.ijsr.net/getabstract.php?paperid=SR26327020400, DOI: https://dx.doi.org/10.21275/SR26327020400