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Case Studies | Dermatology | Volume 15 Issue 3, March 2026 | Pages: 38 - 40 | India
Recurrent Henoch Schonlein Purpura in Association with Cytomegalovirus - A Case Report
Abstract: Henoch-Schonlein purpura is an immunoglobulin A (IgA)-immune complex mediated leukocytoclastic vasculitis that classically manifests with palpable purpura, abdominal pain, arthritis, and hematuria or proteinuria. The condition is much more predominant in children (90% of cases) and commonly follows an upper respiratory infection. [1] It is a systemic hypersensitivity vasculitis caused by the deposition of immune complexes in small blood vessels, including the renal glomeruli and mesangium. In the skin, the presentation is with non-thrombocytopenic purpura [2] Bacterial infections, most commonly group A streptococci, viral infections (Parvovirus, Epstein Barr virus, Varicella zoster virus), allergens, drugs, vaccines have been cited as risk factors. [3][4]. The clinical presentation of IgA vasculitis in adults is similar to that in children. However, in adults, there are two main differences; abdominal symptoms are less common, but renal involvement is more significant, including end-stage kidney disease (ESKD) . Importantly, adults with no known trigger for developing IgA vasculitis should be investigated for solid-organ malignancy, a recognized risk factor [5]. We present a case of recurrent Henoch Schonlein purpura in a 24 year old male. He presented with purpuric lesions on lower limbs, bilaterally symmetrical. No prior history of sore throat or abdominal pain was there. Histopathology confirmed small vessel vasculitis. His viral markers screening showed positive for cytomegalovirus IgG antibody. There was no underlying collagen vascular disorder or malignancy. Henoch Schonlein (HS) purpura associated with cytomegalovirus (CMV) IgG positivity is a rare association with very few cases reported in literature.
Keywords: Henoch Schonlein purpura, IgA vasculitis, cytomegalovirus
How to Cite?: Natasha Panesar, "Recurrent Henoch Schonlein Purpura in Association with Cytomegalovirus - A Case Report", Volume 15 Issue 3, March 2026, International Journal of Science and Research (IJSR), Pages: 38-40, https://www.ijsr.net/getabstract.php?paperid=SR26227215302, DOI: https://dx.dx.doi.org/10.21275/SR26227215302