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Case Studies | Medical Surgical | Volume 15 Issue 2, February 2026 | Pages: 1167 - 1170 | Argentina
High-Grade Small Cell Neuroendocrine Carcinoma of the Parotid Gland: A Case Report
Abstract: High-grade small cell neuroendocrine carcinoma of the parotid gland is an uncommon and aggressive malignancy, representing less than one percent of salivary gland tumors (1,2). Distinguishing primary parotid involvement from metastatic disease, particularly pulmonary carcinoma or Merkel cell carcinoma, remains diagnostically demanding (3). An eighty-one-year-old male presented with a left parotid mass and underwent total parotidectomy with facial nerve preservation. Histopathology revealed a small cell neuroendocrine carcinoma confirmed by immunohistochemical markers including chromogranin A, synaptophysin, CD56, INSM1, and a high Ki-67 index. Imaging excluded an alternative primary origin. The patient declined adjuvant therapy. This case underscores the diagnostic value of immunohistochemistry and highlights the clinical course of this rare entity.
Keywords: Parotid gland carcinoma, Small cell neuroendocrine tumor, Salivary gland malignancy, Immunohistochemistry, Rare head and neck cancer
How to Cite?: D' Addino J, Pigni M, Hughes W, Starling M, D' Addino F, Grosso C, "High-Grade Small Cell Neuroendocrine Carcinoma of the Parotid Gland: A Case Report", Volume 15 Issue 2, February 2026, International Journal of Science and Research (IJSR), Pages: 1167-1170, https://www.ijsr.net/getabstract.php?paperid=SR26216180952, DOI: https://dx.dx.doi.org/10.21275/SR26216180952