The Unusual Culprit: Vitamin D Deficiency as a Rare Cause of Resistant Hypertension
Abstract: Resistant hypertension is defined as blood pressure that remains above target despite the use of three antihypertensive agents of different classes, including a diuretic. While essential hypertension is the most common diagnosis, secondary causes must be rigorously investigated. This case report highlights a 26 year old female presenting with hypertensive emergency and subsequent resistant hypertension. Extensive workup ruled out common secondary causes but revealed severe Vitamin D deficiency and associated secondary hyperparathyroidism. Following Vitamin D supplementation and normalization of levels, the patient's blood pressure was successfully controlled with a reduced drug regimen. This case suggests that Vitamin D deficiency, via its role in the Renin-Angiotensin-Aldosterone System (RAAS) and parathyroid hormone regulation, can be a treatable contributor to resistant hypertension.
Keywords: Resistant Hypertension, Vitamin D Deficiency, Secondary Hyperparathyroidism, RAAS, Hypertensive Emergency
How to Cite?: Dr. Puppala Suraj Sai Maadhav, Dr. Gubbala Charanya Lakshmi, "The Unusual Culprit: Vitamin D Deficiency as a Rare Cause of Resistant Hypertension", Volume 15 Issue 2, February 2026, International Journal of Science and Research (IJSR), Pages: 575-576, https://www.ijsr.net/getabstract.php?paperid=SR26208211426, DOI: https://dx.doi.org/10.21275/SR26208211426