A Correlative Study of Cardiac Enzymes and Diastolic Dysfunction in Patients with Acute Coronary Syndrome

Priyadharshini S, Saritha Narayanan K

Abstract: Background: Acute Coronary Syndrome (ACS) is a leading cause of global morbidity and mortality. While systolic function is routinely assessed, the role of diastolic dysfunction (DD) and its correlation with the extent of myocardial injury, as indicated by cardiac enzymes, is increasingly recognized. This study aimed to evaluate the prevalence of DD in ACS patients and examine its relationship with Creatine Kinase-MB (CK-MB) levels. Methods: A cross-sectional study was conducted on 150 patients admitted with ACS. Diastolic function was assessed via 2D Echocardiography and classified as normal, impaired LV relaxation (Grade 1), or pseudonormal/restrictive (Grade 2/3/4). CK-MB levels were measured upon admission. Statistical analysis was performed using SPSS. Results: The mean age was 49.87 years with a near-equal gender distribution. A highly significant positive correlation was found between CK-MB levels and the severity of DD (Spearman's rho = 0.854, p<0.001). Mean CK-MB levels were 6.34 ng/mL, 34.97 ng/mL, and 70.37 ng/mL for normal, Grade 1, and Grade 2/3/4 DD, respectively. A significant association was found between smoking status and DD grades (p=0.019), though with an unexpected inverse relationship. Trends suggested worse DD with higher BMI and comorbidities like diabetes, though not statistically significant. Conclusion: There is a strong correlation between the severity of diastolic dysfunction and elevated CK-MB levels in ACS patients. Early echocardiographic assessment of diastolic function, alongside cardiac enzyme monitoring, is crucial for risk stratification and guiding management, emphasizing lifestyle interventions like weight management and smoking cessation.

Keywords: Diastolic Dysfunction, CK-MB, Acute Coronary Syndrome, Comorbidities, Echocardiography

How to Cite?: Priyadharshini S, Saritha Narayanan K, "A Correlative Study of Cardiac Enzymes and Diastolic Dysfunction in Patients with Acute Coronary Syndrome", Volume 15 Issue 1, January 2026, International Journal of Science and Research (IJSR), Pages: 494-497, https://www.ijsr.net/getabstract.php?paperid=SR26107092326, DOI: https://dx.doi.org/10.21275/SR26107092326