Evaluation of Efficacy of Pregabalin and Tramadol on Anxiety and Sedation in Total Knee Arthroplasty Patients

Dr. Koramutla Pradeep Kumar, Gudaru Jagadesh

Abstract: Background: Anticonvulsant medications are established treatments for neuropathic pain, role of pregabalin was studied in the latest research that it has a role in the Acute and post operative pain. Pregabalin was taken up for the study to primarily assess anxiety and sedation when compared to tramadol in patients undergoing elective Total Knee Arthroplasty. Methods: Study group included 50 patients between 20-60 yrs belonging to ASA-I and II, The patients were randomly allocated into 2 groups of 25 each. Tramadol group received 100mg capsule while the pregabalin group received 150mg capsule orally 1hr before the anesthetic induction. Multimodal analgesia included femoral nerve 3 in 1 nerve block and rescue analgesics diclofenac was used. The primary outcome in our study was Anxiety and sedation. Results: Pregabalin showed statistically significant anxiolytic effects compared to tramadol but was associated with less sedation to tramadol. Whereas Pregabalin had less number of postoperative complications of nausea, vomiting and drowsiness. Conclusion: The results of this study support, the clinical use of pregabalin in the post surgical setting for relieving Anxiety alone. Whereas tramadol was better in only post operative pain and mild sedation.

Keywords: pregabalin, Tramadol, Total knee arthroplasty, sedation, Anxiety

How to Cite?: Dr. Koramutla Pradeep Kumar, Gudaru Jagadesh, "Evaluation of Efficacy of Pregabalin and Tramadol on Anxiety and Sedation in Total Knee Arthroplasty Patients", Volume 15 Issue 1, January 2026, International Journal of Science and Research (IJSR), Pages: 213-215, https://www.ijsr.net/getabstract.php?paperid=SR26103163042, DOI: https://dx.doi.org/10.21275/SR26103163042