Male Breast Metastasis from Esophageal Adenocarcinoma Diagnosed by FNAC - A Case Report with Literature Review

Lumen A, K. C. Sharan, Swetha Param, Debasis Gochhait, Nachiappa Ganesh Rajesh

Abstract: Metastasis to the male breast from extra-mammary sources is exceedingly rare, with only a few cases reported in medical literature, particularly from esophageal carcinomas. This article presents the rare case of a 59-year-old male who developed a breast lump and cervical lymphadenopathy without axillary involvement or nipple changes. Fine Needle Aspiration Cytology (FNAC) of both sites revealed similar malignant features, raising suspicion for metastasis rather than primary breast cancer. Subsequent endoscopic biopsy confirmed esophageal adenocarcinoma. Immunohistochemistry further supported the diagnosis, highlighting the value of CK7 positivity and GATA3/CK20 negativity. This case underscores the importance of clinical history, comprehensive examination, and targeted immunocytochemistry in distinguishing metastatic lesions from primary malignancies, thereby preventing misdiagnosis and unnecessary treatments.

Keywords: Male breast metastasis, FNAC, Esophageal adenocarcinoma, Cytodiagnosis, Immunohistochemistry

How to Cite?: Lumen A, K. C. Sharan, Swetha Param, Debasis Gochhait, Nachiappa Ganesh Rajesh, "Male Breast Metastasis from Esophageal Adenocarcinoma Diagnosed by FNAC - A Case Report with Literature Review", Volume 14 Issue 10, October 2025, International Journal of Science and Research (IJSR), Pages: 150-154, https://www.ijsr.net/getabstract.php?paperid=SR25929110540, DOI: https://dx.doi.org/10.21275/SR25929110540