Comparative Study of the Transfusion Effect of Single Donor Apheresis Platelets Versus Random Donor Platelets in the Management of Severe Dengue Infection in Children

D Abdul Shareef

Abstract: Background: Severe dengue with thrombocytopenia often necessitates platelet transfusion. Both random donor platelets (RDP) and single donor apheresis platelets (SDP) are used, but comparative pediatric data are limited. Objective: To evaluate and compare the transfusion efficacy of SDP and RDP in children with severe dengue. Methods: This prospective study (Jan?December 2024) included 60 pediatric patients at ACS Medical college and Hospital Chennai India, requiring platelet transfusion for severe dengue (30 SDP, 30 RDP). Platelet increments, corrected count increment (CCI), and percentage recovery (PR) were measured 24 hours post-transfusion. Results: SDP recipients had significantly higher platelet increments at 24 hours compared to RDP (p<0.01). However, CCI and PR were comparable between groups, with no statistically significant difference. Mean hospital stay was similar (SDP: 7.50?2.07 days; RDP: 7.0?1.82 days). Conclusion: While SDP achieved higher immediate platelet count increments, both SDP and RDP showed similar CCI and PR outcomes. SDP offers advantages in reducing donor exposure and enabling leukoreduction, but due to higher cost and technical demands, its use in resource-limited settings should be selective.

Keywords: Severe dengue, thrombocytopenia, platelet transfusion, single donor apheresis platelets, random donor platelets

How to Cite?: D Abdul Shareef, "Comparative Study of the Transfusion Effect of Single Donor Apheresis Platelets Versus Random Donor Platelets in the Management of Severe Dengue Infection in Children", Volume 14 Issue 8, August 2025, International Journal of Science and Research (IJSR), Pages: 711-714, https://www.ijsr.net/getabstract.php?paperid=SR25813222106, DOI: https://dx.doi.org/10.21275/SR25813222106