Assessment of the Antigenotoxic Effect of Aloe Vera Gel Extract on 2-Chloroacetamide Induced Genotoxicity in Allium Cepa Cells

Smita S. Kharkale-Bhuyar

Abstract: The growing exposure to environmental mutagens has sparked a search for natural agents that can counteract their effects. This study investigated the potential antigenotoxic properties of Aloe vera gel extract using the Allium cepa assay. Onions were exposed to varying concentrations of A. vera gel extract (6.25% to 100%) in combination with 2-chloroacetamide, a known mutagen. The results showed that A. vera gel extract inhibited cell division and root growth in a dose-dependent manner when combined with 2-chloroacetamide. However, lower doses of A. vera (6.25% to 25%) reduced the genotoxicity of 2-chloroacetamide, while higher doses (50% to 100%) exacerbated its toxic effects. These findings suggest that A. vera gel extract possesses antigenotoxic properties at lower concentrations, making it a potential candidate for the development of anticancer agents.

Keywords: Aloe vera, 2-chloroacetamide Allium cepa, Antimutagenicity, Mutagenicity

How to Cite?: Smita S. Kharkale-Bhuyar, "Assessment of the Antigenotoxic Effect of Aloe Vera Gel Extract on 2-Chloroacetamide Induced Genotoxicity in Allium Cepa Cells", Volume 14 Issue 8, August 2025, International Journal of Science and Research (IJSR), Pages: 513-515, https://www.ijsr.net/getabstract.php?paperid=SR25808130749, DOI: https://dx.doi.org/10.21275/SR25808130749