Downloads: 6
India | Pathology | Volume 14 Issue 7, July 2025 | Pages: 1268 - 1270
Histopathological Study of Tumor Budding as Prognostic Marker in Invasive Breast Carcinoma
Abstract: Background: Tumor budding (TB), defined as single cells or small clusters of up to five tumor cells at the invasive front, is an emerging histopathological marker associated with aggressive behavior in various cancers. Its prognostic significance in invasive breast carcinoma (IBC) remains underexplored. This study evaluates TB as a prognostic marker in IBC and its correlation with clinicopathological parameters. Methods: A retrospective analysis was conducted on 100 mastectomy specimens of histopathologically confirmed IBC, no special type (NST), from January 2022 to June 2023. Tumor budding was assessed using hematoxylin and eosin (H&E) stained slides, graded per the International Tumor Budding Consensus Conference (ITBCC) criteria. Associations with tumor size, lymph node metastasis, lymphovascular invasion (LVI), perineural invasion (PNI), hormone receptor status, and survival outcomes were analyzed using Chi-square tests and Kaplan-Meier survival analysis. Results: High-grade TB was observed in 38% of cases and was significantly as- sociated with larger tumor size (p=0.012), lymph node metastasis (p<0.001), LVI (p=0.003), and worse overall survival (p<0.001). Hormone receptor-positive tumors showed a higher incidence of high-grade TB (p=0.008). Multivariate analysis confirmed TB as an independent prognostic factor (HR 3.85, p<0.001). Conclusion: Tumor budding is a significant and independent prognostic marker in IBC, correlating with adverse clinicopathological features and poorer survival. Its inclusion in routine histopathological reporting could enhance risk stratification and guide therapeutic decisions.
Keywords: Tumor budding, invasive breast carcinoma, prognostic marker, epithelial-mesenchymal transition, histopathology
How to Cite?: Dr. Maureen Mushtaq, Dr. K. C. Goswami, "Histopathological Study of Tumor Budding as Prognostic Marker in Invasive Breast Carcinoma", Volume 14 Issue 7, July 2025, International Journal of Science and Research (IJSR), Pages: 1268-1270, https://www.ijsr.net/getabstract.php?paperid=SR25718053828, DOI: https://dx.doi.org/10.21275/SR25718053828
Received Comments
No approved comments available.