Comparative Estimation of C-Reactive Protein in Gingival Crevicular Fluid of Patients with Periodontitis and Myocardial Infarction in Remission

Gopireddy Keerthi Reddy, Kranti K Reddy

Abstract: Background: C-reactive protein (CRP), a sensitive marker of systemic inflammation, has been implicated in the pathogenesis of both periodontitis and cardiovascular diseases. Gingival crevicular fluid (GCF) reflects local inflammatory activity and may serve as a non-invasive medium to explore the periodontal-cardiovascular interface. Aim: To estimate and compare C-Reactive Protein levels in gingival crevicular fluid of patients with chronic periodontitis, and those with chronic periodontitis and a history of myocardial infarction (MI) in remission. Materials and Methods: This cross-sectional study included 60 participants divided into three groups (n = 20 each): Group I (healthy controls), Group II (chronic periodontitis), and Group III (chronic periodontitis with MI in remission). GCF was collected using calibrated microcapillary pipettes, and CRP concentrations were quantified using a high-sensitivity ELISA. Intergroup comparisons were performed using ANOVA and post hoc analysis. Results: Mean GCF CRP levels were significantly higher in Group III compared to Groups II and I (p < 0.001), demonstrating a graded increase corresponding to systemic disease burden. Conclusion: Elevated GCF CRP levels in patients with periodontitis and MI in remission suggest an enhanced local inflammatory response, reinforcing the bidirectional link between periodontal and cardiovascular health.

Keywords: C-reactive protein, gingival crevicular fluid, periodontitis, myocardial infarction, inflammation, biomarkers

How to Cite?: Gopireddy Keerthi Reddy, Kranti K Reddy, "Comparative Estimation of C-Reactive Protein in Gingival Crevicular Fluid of Patients with Periodontitis and Myocardial Infarction in Remission", Volume 14 Issue 7, July 2025, International Journal of Science and Research (IJSR), Pages: 395-405, https://www.ijsr.net/getabstract.php?paperid=SR25703164422, DOI: https://dx.doi.org/10.21275/SR25703164422