Comparative Evaluation of Porcine-Derived Barrier Membranes for Alveolar Bone Regeneration in a Canine Model

Ying Wang, Junge Xu, Hui Sun, Manqi Yin, Lixin Xu

Abstract: This study compares the physicochemical and osteogenic properties of two porcine-derived absorbable membranes small intestinal submucosa (Chenggu Kuai?) and porcine peritoneum (Lando?) in the context of alveolar bone regeneration. Using a beagle dog model, bilateral mandibular extraction sockets were filled with identical bone graft materials and covered with the respective membranes. Key measurements included pH levels, mechanical strength, bone dimensions, and bone volume using Micro-CT and histological analysis. Results showed that both membranes supported bone regeneration without significant differences in bone volume or healing response. However, the Chenggu Kuai? Oral Collagen Membrane exhibited better mechanical properties and a more neutral pH, indicating greater biocompatibility and potential for clinical application.

Keywords: Collagen membrane, Guided bone regeneration, Porcine biomaterials, Alveolar bone, Animal study

How to Cite?: Ying Wang, Junge Xu, Hui Sun, Manqi Yin, Lixin Xu, "Comparative Evaluation of Porcine-Derived Barrier Membranes for Alveolar Bone Regeneration in a Canine Model", Volume 14 Issue 7, July 2025, International Journal of Science and Research (IJSR), Pages: 440-447, https://www.ijsr.net/getabstract.php?paperid=SR25629155605, DOI: https://dx.doi.org/10.21275/SR25629155605