Application of oXiris-CRRT in Managing Septic Shock-Induced Acute Kidney Injury: A Clinical Case Report

Lordian Nunci, Olta Ajasllari, Deniona Nunci, Md, Armida Ajasllari, Dr. Krenar Lilaj, Ditila Doracaj

Abstract: This case report outlines the clinical application of continuous renal replacement therapy (CRRT) using the oXiris adsorbing filter in a 35-year-old male patient diagnosed with acute kidney injury (AKI) secondary to septic shock and diabetic ketoacidosis (DKA). The patient initially showed improvement in renal function, hemodynamic stability, and inflammatory markers following oXiris-CRRT. However, the onset of ARDS on day 10 required a reinitiation of therapy. Subsequent treatment cycles led to significant recovery in oxygenation, renal parameters, and reduced vasopressor dependence, ultimately resulting in patient discharge. This case underscores the potential of oXiris-CRRT in managing systemic inflammation and organ dysfunction, while also highlighting the need for vigilance against ARDS progression in septic patients. Further studies are recommended to explore predictive markers and optimize therapy protocols. The purpose of this case report is to evaluate the clinical efficacy of oXiris-CRRT in managing acute kidney injury due to septic shock, with particular focus on its role in modulating inflammation and preventing complications like ARDS.

Keywords: acute kidney injury, septic shock, oXiris filter, CRRT, ARDS