A Comparative Study of Ascorbic Acid and Hydrocortisone vs. Hydrocortisone Alone in Improving Hemodynamics, Recovery and Prognosis in Septic Shock Patients in the ICU

Dr. Yash R. Shah, Dr. Jessy Vennel

Abstract: Background: Hemodynamic instability and a delayed recovery are common outcomes of septic shock, a serious illness with a high morbidity and fatality rate. Conventional treatment plans emphasize vasopressors and fluid resuscitation; Hydrocortisone is frequently administered because of its anti - inflammatory qualities. According to recent research, adding high - dose Ascorbic acid may have synergistic effects that could improve hemodynamics, enable faster extubation, and improve prognosis overall for patients. Objective: With an emphasis on hemodynamic stability, recovery durations, and prognosis, this study compares the effects of combined Ascorbic acid and Hydrocortisone therapy against Hydrocortisone alone in patients with septic shock. Method: In a tertiary intensive care unit, a prospective, randomized, controlled trial was carried out.20 patients with septic shock were randomly assigned, equally to one of two groups: Group B received Hydrocortisone alone, while Group A received Ascorbic acid and Hydrocortisone together. Vasopressor needs, duration to extubation, length of stay in the intensive care unit, mean arterial pressure (MAP), and overall survival rates were important outcomes. Inflammatory indicators and hemodynamic parameters were closely observed and contrasted. Result: According to preliminary results, the group treated with Hydrocortisone plus Ascorbic acid showed improved hemodynamic stability, required fewer doses of vasopressors, and experienced extubation earlier than the group treated with Hydrocortisone alone. Additionally, Group A patients had trends toward better long - term outcomes, such as lower mortality, and had shorter ICU stays. Conclusion: Better hemodynamics, an earlier recovery, and an improved prognosis are just a few of the apparent benefits of using Ascorbic acid in addition to Hydrocortisone when treating patients with septic shock. These results point to a promising adjuvant treatment that may enhance critical care outcomes for patients with septic shock.

Keywords: Septic shock, Ascorbic acid, Hydrocortisone, Critical care, ICU, Hemodynamic stability, SOFA score, Sepsis treatment

How to Cite?: Dr. Yash R. Shah, Dr. Jessy Vennel, "A Comparative Study of Ascorbic Acid and Hydrocortisone vs. Hydrocortisone Alone in Improving Hemodynamics, Recovery and Prognosis in Septic Shock Patients in the ICU", Volume 14 Issue 5, May 2025, International Journal of Science and Research (IJSR), Pages: 856-860, https://www.ijsr.net/getabstract.php?paperid=SR25513003444, DOI: https://dx.doi.org/10.21275/SR25513003444