Disseminated Histoplasmosis - An Incidental Finding

Dr. Prateek Sapra

Abstract: Histoplasma capsulatum, a dimorphic fungus, infects humans through inhalation of microconidia, transforming into yeast in the alveoli. We report a 42 - year - old woman with type II diabetes and hypertension who presented with decreased urine output, fatigue, and edema. Investigations revealed pancytopenia, renal dysfunction, and proteinuria. Bone marrow biopsy confirmed Histoplasma capsulatum by PAS staining. This case emphasizes considering histoplasmosis in patients with chronic illness and pancytopenia, even in non - endemic areas, highlighting the diagnostic importance of bone marrow examination for timely management.

Keywords: Disseminated Histoplasmosis, Pancytopenia, Bone Marrow Biopsy