Correlation of Serological and Inflammatory Markers with Radiographic Findings in Rheumatoid Arthritis Patients
Abstract: Background: Rheumatoid Arthritis is a chronic inflammatory disease characterized by joint damage and systemic complications. This study aimed to investigate the correlation between Rheumatoid Factor, Anti - Cyclic Citrullinated, C - Reactive Protein, and Erythrocyte Sedimentation Rate with radiographic findings in RA patients. Additionally, the association of psychiatric parameters with disease severity was assessed. Methods: A pilot cross - sectional study was conducted on 30 RA patients. Biomarker levels were measured using chemiluminescence and the Westergren method. Radiographic evaluation included joint erosion, joint space narrowing, and osteophyte formation assessed via the Sharp/van der Heijde scoring system. Psychiatric parameters such as depression, anxiety, sleep disturbance, coping difficulties, and cognitive impairment were recorded. Correlation and group comparisons were performed using SPSS. Results: Patients with severe RA had significantly higher RF, Anti - CCP, CRP, and ESR levels than those with mild and moderate disease. Radiographic findings showed progressive joint damage with increasing disease severity. Psychiatric symptoms, particularly anxiety (60%) and depression (53.3%), were more prevalent in severe cases. A strong correlation was observed between inflammatory markers and radiographic severity (p
Keywords: Rheumatoid Arthritis, Inflammatory Biomarkers, Radiographic Severity, Psychiatric Comorbidities, Disease Progression
How to Cite?: Shivmohan Singh, "Correlation of Serological and Inflammatory Markers with Radiographic Findings in Rheumatoid Arthritis Patients", Volume 14 Issue 4, April 2025, International Journal of Science and Research (IJSR), Pages: 1831-1835, https://www.ijsr.net/getabstract.php?paperid=SR25421111445, DOI: https://dx.doi.org/10.21275/SR25421111445