A Study to Assess the Safety and Efficacy of Preoperative vs Postoperative Per Rectal Misoprostol in Lower Segment Cesarean Section to Prevent Postpartum Hemorrhage
Abstract: Background: Many global gains in reducing maternal mortality can be attributed to the developments in preventing and treating postpartum hemorrhage (PPH). Misoprostol, a synthetic PGE1 analog has been extensively studied in the prevention and treatment of PPH after vaginal delivery, however, its use in conjunction with cesarean delivery has not been investigated as much. The study aimed to assess the effect of rectally administered misoprostol on blood loss before and after cesarean delivery. Material and Methods: This was a prospective comparative study done in our obstetrics and gynecology department at Sarojini Naidu Medical College, Agra. It involved a total of 150 women who were found to be eligible for the study after meeting the inclusion criteria. Its objective was to compare the effectiveness of the rectally administered 600?g misoprostol pre - operatively versus post - operatively in minimizing intraoperative blood loss and prevention of PPH in cesarean delivery. The outcomes studied were intraoperative and postoperative blood loss, changes in hemoglobin concentration, and hematocrit, maternal adverse effects, need for additional uterotonics and surgical interventions. The level of significance was set at
Keywords: postpartum hemorrhage, misoprostol, preoperative misoprostol, postoperative misoprostol
How to Cite?: Apurva Patel, "A Study to Assess the Safety and Efficacy of Preoperative vs Postoperative Per Rectal Misoprostol in Lower Segment Cesarean Section to Prevent Postpartum Hemorrhage", Volume 14 Issue 4, April 2025, International Journal of Science and Research (IJSR), Pages: 717-720, https://www.ijsr.net/getabstract.php?paperid=SR25407213025, DOI: https://dx.doi.org/10.21275/SR25407213025