Comparison of Dexmedetomidine and Fentanyl as Adjuvants to Intrathecal Levobupivacaine in Patients Undergoing Infra-Umbilical Surgeries
Abstract: Background: Spinal anaesthesia is a common technique for infra-umbilical surgeries; however, its limited duration necessitates rescue analgesics. Aim: To compare the efficacy of Fentanyl (25mcg) vs. Dexmedetomidine (5mcg) as adjuvants to intrathecal Hyperbaric Levobupivacaine in infra-umbilical surgeries with respect to characteristics of spinal blockade, hemodynamic effects, post-op analgesia, sedation, motor block duration, and adverse effects. Study Design: Prospective, Randomized & Double-blind study. Material And Methods: The study was conducted at Hi-Tech Medical College & Hospital, Bhubaneswar, from March 2023 to February 2025. The study included 120 ASA I and II patients of either sex, aged 18-60 years, scheduled for elective infra-umbilical surgeries. Patients were randomly assigned to two groups: Group D: 0.5% Hyperbaric Levobupivacaine 2.5 ml + 5 mcg Dexmedetomidine. Group F: 0.5% Hyperbaric Levobupivacaine 2.5 ml + 25 mcg Fentanyl Haemodynamic Parameters such as Heart Rate, Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure, SpO2, were recorded at baseline. Spinal anaesthesia was administered at the L3-L4 interspace. Vitals and block characteristics were monitored at specified intervals intraoperatively and postoperatively. Side effects were documented and managed accordingly. Postoperative rescue analgesia was given as per requirement. Results and Discussion: This prospective, randomized, double-blind study compared the effects of Dexmedetomidine (5 mcg) and Fentanyl (25 mcg) as adjuvants to 0.5% hyperbaric Levobupivacaine in 120 patients undergoing infra-umbilical surgeries. The findings indicate that Dexmedetomidine significantly prolongs sensory and motor blockade, provides superior postoperative analgesia, and delays rescue analgesia requirements compared to Fentanyl (p
Keywords: Spinal anaesthesia, Intrathecal adjuvants, Dexmedetomidine, Fentanyl, Postoperative analgesia
How to Cite?: Dr. Pulak Kumar Sahoo, Dr. Sucheta Pattanayak, "Comparison of Dexmedetomidine and Fentanyl as Adjuvants to Intrathecal Levobupivacaine in Patients Undergoing Infra-Umbilical Surgeries", Volume 14 Issue 3, March 2025, International Journal of Science and Research (IJSR), Pages: 683-687, https://www.ijsr.net/getabstract.php?paperid=SR25312213953, DOI: https://dx.doi.org/10.21275/SR25312213953