The Effect of Blood Glucose Level and Body Mass Index on Standardized Uptake Value on PET / CT

Esra Salam, Mohamed Alfadil

Abstract: A review of Introduction: In malignant tissue and healthy organs in 18F - FDG PET/CT, glucose metabolism and physiological factors interact to affect 18F - FDG absorption. The present work evaluates on 18F - FDG absorption in tumors and biodistribution in normal tissues of organs the effects of blood glucose levels (BGL), Body mass index, and FDG dosage. Procedures: Analyzed in 99 individuals (43 male - 56 female), 18F - FDG PET/CT shows mean age of 67.6 years with BGL ranging from 130 to 200 mg/dl and body mass index ranging from 18.3 to 46.4. Measuring the target organs (brain, liver, spleen, and heart), we found their mean standardized uptake value (SUV). For statistical relevance, variations in SUV among patients with varying BGLs, BMI, FDG, heigh, weight, and age were examined and matched. Results: Brain_SUV improves with increasing FDG_dose. FDG dosage and Heart SUV The study of this table revealed a strong link between glucose level and heart SUV; hence, the outcome of this table indicated that patient weight has a major influence on liver SUV. (P value.016) The data show a strong association between spleen SUV and glucose level. (p - value.032) Age and brain SUV show a clear link, according to the results. (P - value.002). Conclusion: SUV values in several organs are greatly influenced by FDG dosage. Brain SUV rises with FDG dosage. As FDG dose rises, heart and liver SUV drop. Glucose levels lower SUV in the spleen and the heart. suggests in these areas an inverse link between glucose metabolism and FDG absorption. Variations in SUV are influenced by physical characteristics including age, height, weight, BMI. Senior citizens have smaller brain SUV. Taller people have lower SUV in the brain and spleen. Greater SUV in the liver corresponds with increased weight and BMI.

Keywords: Blood glucose level, body mass index, flourodeoxy glucose