A Comparative Study on the Effectiveness of Misoprostol Moistened with Acetic Acid versus Saline for Second-Trimester Pregnancy Termination
Abstract: Introduction: Second-trimester pregnancy termination presents significant medical challenges, requiring safe and effective methods. Misoprostol, a prostaglandin E1 analog, is widely used due to its affordability, ease of administration, and efficacy. Recent research suggests that moistening misoprostol with acetic acid may enhance its absorption and effectiveness. This study compares the effectiveness of misoprostol moistened with acetic acid versus saline in second-trimester pregnancy termination. Methods: A prospective hospital-based interventional study was conducted at a Tertiary healthcare centre, from December 2022 to January 2024. Sixty women aged 18-40 years with singleton pregnancies of 14-24 weeks were randomly allocated into two groups: Group A received misoprostol moistened with saline, while Group B received misoprostol moistened with acetic acid. The primary outcome measured was the induction-abortion interval. Secondary outcomes included mean misoprostol dose, side effects, complications, and hospital stay duration. Results: The mean induction-abortion interval was significantly shorter in Group B (18.01 ? 3.1 hours) compared to Group A (21.96 ? 2.5 hours, p
Keywords: Misoprostol, Second-trimester abortion, Acetic acid, Saline, Induction-abortion interval
How to Cite?: Dr. Shrankhla Paliwal, Dr. Suniti Verma, Dr. R. N. Sehra, Dr. Sukhwinder Kaur, "A Comparative Study on the Effectiveness of Misoprostol Moistened with Acetic Acid versus Saline for Second-Trimester Pregnancy Termination", Volume 14 Issue 3, March 2025, International Journal of Science and Research (IJSR), Pages: 575-578, https://www.ijsr.net/getabstract.php?paperid=SR25308230751, DOI: https://dx.doi.org/10.21275/SR25308230751