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Analysis Study Research Paper | Dermatology | India | Volume 14 Issue 3, March 2025 | Popularity: 4.4 / 10
Study to Evaluate Pattern of Transforming Growth Factor-β1 Gene Polymorphism in Psoriasis Vulgaris Patients in Central Rajasthan?s Population
Dr. Abhinav Awasthi, Dr. Rajkumar Kothiwala, Dr. Kritika Gahlot
Abstract: Psoriasis is an immune-mediated inflammatory disease with a genetic component, characterized by keratinocyte hyperproliferation and angiogenesis. Transforming growth factor-β1 (TGF-β1), the predominant isoform in the skin, plays a dual role, inhibiting keratinocyte growth or promoting proliferation under inflammatory conditions. Elevated TGF-β1 levels have been linked to psoriasis severity, but the mechanisms behind this elevation remain unclear. Genetic polymorphisms in the TGF-β1 gene on chromosome 19 have been associated with various immune-mediated diseases, though their role in psoriasis is not fully understood. This cross-sectional study investigates the association of TGF-β1 gene polymorphism at codon 10 with psoriasis susceptibility in Central Rajasthan. Sixty-three psoriasis patients were recruited from dermatology clinics, with ethical approval and informed consent. Blood samples were analysed using PCR and restriction fragment length polymorphism (RFLP) techniques to identify genotypes (Leu/Leu [TT], Leu/Pro [TC], and Pro/Pro [CC]). The genotypic distribution showed 11.1% with CC, 85.7% with TC, and 0% with TT, indicating a significant predominance of the TC genotype. All patients with CC genotype had a positive family history.
Keywords: Psoriasis, TGF-β1, gene polymorphism, codon 10, PCR, RFLP
Edition: Volume 14 Issue 3, March 2025
Pages: 147 - 150
DOI: https://www.doi.org/10.21275/SR25228064858
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