Effectiveness of Ondansetron Alone Versus Ondansetron-Dexamethasone in the Prevention of Postoperative Nausea and Vomiting Following Laparoscopic Cholecystectomy
Abstract: Postoperative nausea and vomiting (PONV) continue to be generally observed and troubling side effects of general anaesthesia, especially after laparoscopic surgeries. Ondansetron, a selective 5-HT3 receptor antagonist, is frequently implemented for the prophylaxis of PONV. However, concomitant medication may increase its efficacy. This prospective, randomized, double-blind study was performed over 18 months at a tertiary care teaching hospital to assess the efficacy of ondansetron monotherapy compared to a combination of ondansetron-dexamethasone is preventing PONV after laparoscopic cholecystectomy. There were 60 patients having ASA physical status I and II, and their age lied between 18 and 60 years. They were split into two groups of 30 people each at random. Group A was provided 4 mg of ondansetron. A visual analogue scale was used to compute the frequency and intensity of nausea, retching, and vomiting at 0, 2, 4, 8, 12, and 24-hours following surgery. The combined group showed a significantly reduced incidence of nausea, retching, and vomiting, necessitating substantially less rescue antiemetic medication in comparison to the ondansetron-only group (p
Keywords: Dexamethasone, General anaesthesia, Laparoscopic cholecystectomy, Ondansetron, Postoperative nausea and vomiting
How to Cite?: Dr. Harleen Kaur, Dr. Melchisedec Singh, Dr. Valsamma Abraham, "Effectiveness of Ondansetron Alone Versus Ondansetron-Dexamethasone in the Prevention of Postoperative Nausea and Vomiting Following Laparoscopic Cholecystectomy", Volume 15 Issue 1, January 2026, International Journal of Science and Research (IJSR), Pages: 115-120, https://www.ijsr.net/getabstract.php?paperid=SR251231212718, DOI: https://dx.doi.org/10.21275/SR251231212718