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Review Papers | Radiology and Medical Imaging Sciences | Volume 14 Issue 12, December 2025 | Pages: 1686 - 1690 | India
MRI in Early Detection of Neurodegenerative Disorders: A Comprehensive Review
Abstract: Progressive loss of neurons is a feature of neurodegenerative disorders such as Alzheimer's, Parkinson's, and Multiple Sclerosis. For prompt intervention, early detection is essential. A sensitive and non-invasive method, magnetic resonance imaging (MRI) can identify abnormalities in the brain before clinical symptoms manifest. For the purpose of early diagnosis, this study assesses both conventional and cutting-edge MRI methods, including volumetric analysis, diffusion tensor imaging, functional MRI, susceptibility-weighted imaging, and quantitative susceptibility mapping. We also talk about new MRI applications, difficulties, and opportunities. Objective: Examining how MRI can aid in the early diagnosis of neurodegenerative diseases such Multiple Sclerosis, Parkinson's disease, and Alzheimer's disease is the aim of this review. Aim: This study examines how sophisticated MRI methods?volumetric imaging, fMRI, and DTI?identify early brain alterations in neurodegenerative disorders, frequently prior to the onset of symptoms, emphasizing their use in directing therapy and assessing advantages and disadvantages. Discussion: MRI is essential for the early detection of neurodegenerative illnesses because it can spot anomalies in the brain, such as hippocampal shrinkage or white matter lesions, before symptoms appear. Although accessibility and expense are still barriers, it encourages early diagnosis and treatment planning. Conclusion: When neurodegenerative diseases are detected early, MRI is a useful tool for identifying abnormalities in the brain before significant symptoms manifest. Subtle structural and functional anomalies are revealed by advanced techniques like DTI, fMRI, and SWI, which help in early diagnosis and treatment. MRI is crucial for early screening and future treatment of various illnesses due to its advantages, even in the face of obstacles like cost and accessibility.
Keywords: Multiple sclerosis, MRI, Alzheimer's disease, Parkinson's disease, and neurodegenerative illnesses
How to Cite?: Kirti, Zahid Ahmad Rather, Shalu Thakur, Gauri Sharma, Dhiraj Kumar Nath, Anishka Negi, "MRI in Early Detection of Neurodegenerative Disorders: A Comprehensive Review", Volume 14 Issue 12, December 2025, International Journal of Science and Research (IJSR), Pages: 1686-1690, https://www.ijsr.net/getabstract.php?paperid=SR251219183431, DOI: https://dx.dx.doi.org/10.21275/SR251219183431