Comparative Evaluation of the Performance of the Neodocs Point-of-Care Creatinine Kit Versus the Conventional Laboratory Method

Nikunj Malpani, Anurag Meena, Pratik Lodha

Abstract: Chronic kidney disease (CKD) poses a major and growing global health issue, with low- and middle-income nations, such as India, experiencing a disproportionately high impact. The early identification of CKD is often hindered by the lack of access to laboratory facilities in resource-limited areas. Point-of-care (POC) devices for measuring creatinine present a practical alternative, allowing for prompt evaluation and management of kidney function. This study prospectively assessed the analytical performance of the Neodocs POC creatinine kit in comparison to a standard laboratory method (Roche Cobas c 503) using 30 blood samples across three separate batches. The findings showed a strong agreement between ND and reference values, with high correlation coefficients (r = 0.992-0.993) across the tested creatinine concentration ranges (0.1-7.4 mg/dL). ND measurements were closely aligned with those of the reference device, exhibiting minimal bias in low, normal, and high creatinine levels. Precision analyses indicated coefficients of variation of 5.0% in the low range and 1.5-1.6% in the normal and high ranges, demonstrating strong reproducibility. The study supports the Neodocs device's suitability for POC creatinine testing and its potential to improve CKD screening and monitoring, especially in underserved areas. Larger studies involving broader demographic and clinical spectrums are needed to confirm these results and further validate the device's clinical utility. Overall, the Neodocs POC creatinine kit shows promising accuracy and precision, highlighting its value as an accessible, quick, and reliable tool for assessing kidney function in various healthcare settings.

Keywords: Chronic Kidney Disease, Creatinine, Point of Care Device, Validation

How to Cite?: Nikunj Malpani, Anurag Meena, Pratik Lodha, "Comparative Evaluation of the Performance of the Neodocs Point-of-Care Creatinine Kit Versus the Conventional Laboratory Method", Volume 14 Issue 11, November 2025, International Journal of Science and Research (IJSR), Pages: 1675-1678, https://www.ijsr.net/getabstract.php?paperid=SR251124170814, DOI: https://dx.doi.org/10.21275/SR251124170814