Cellular and Extracellular Vesicle-Based Regeneration in Focal Vitiligo: A Novel Approach Using Adipose-Derived MSCs and Exosomes

Naman Somani, Divyang Patel

Abstract: Vitiligo is an acquired autoimmune pigmentary disorder characterized by progressive melanocyte loss, resulting in sharply demarcated depigmented macules. Conventional treatments often yield incomplete or temporary improvement, especially in long-standing cases. Recent advances in regenerative medicine have highlighted the therapeutic potential of mesenchymal stem cells (MSCs) and exosomes in restoring melanocyte function. We report the case of a 48-year-old male with focal vitiligo involving stable depigmented patches on both hands and legs for over two years, treated using a combined intravenous (IV) and intradermal (ID) protocol of donor-derived adipose MSCs and amniotic fluid?derived exosomes. This dual approach was designed to achieve systemic immune modulation alongside localized melanocyte stimulation. Across four treatment sessions, visible perifollicular repigmentation appeared within two weeks, progressing to nearly 90% pigment restoration by three months. No new lesions or adverse events were observed. This case supports the synergistic immunomodulatory and melanocyte-regenerative potential of MSCs and exosomes as an emerging modality for focal vitiligo.

Keywords: Vitiligo, Focal vitiligo, Mesenchymal stem cells, Exosomes, Adipose-derived MSCs, Repigmentation, Immunomodulation, Regenerative therapy

How to Cite?: Naman Somani, Divyang Patel, "Cellular and Extracellular Vesicle-Based Regeneration in Focal Vitiligo: A Novel Approach Using Adipose-Derived MSCs and Exosomes", Volume 14 Issue 11, November 2025, International Journal of Science and Research (IJSR), Pages: 1522-1524, https://www.ijsr.net/getabstract.php?paperid=SR251119125613, DOI: https://dx.doi.org/10.21275/SR251119125613