Analgesic Effect of Dexmedetomidine with Bupivacaine and Bupivacaine Alone in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective Randomized Double-Blinded Comparative Clinical Study

Dr. Amit Kumar Suman, Dr. Neeraj

Abstract: Background: Laparoscopic cholecystectomy (LC) has replaced open cholecystectomy as a standard procedure owing to minimal blood loss, less postoperative pain, faster recovery, and shorter hospital stay. However, visceral pain continues to be a significant postoperative issue. Aim and Objectives: To compare the analgesic efficacy of intraperitoneal and port-site instillation of dexmedetomidine combined with bupivacaine versus bupivacaine alone in patients undergoing laparoscopic cholecystectomy. Methods: A prospective, randomized, double-blinded study was conducted on 80 ASA Grade I?II patients (18?65 years). Patients were divided equally into: Group A: Bupivacaine 0.25% 2 mg/kg (diluted to 60 ml). Group B: Bupivacaine 0.25% 2 mg/kg + Dexmedetomidine 1 ?g/kg (diluted to 60 ml). Pain was measured by the Visual Analogue Scale (VAS) at 0, 2, 6, 12, and 24 h. Time to first analgesic request, total analgesic consumption, hemodynamic stability, adverse effects, and satisfaction were assessed. Results: Duration of analgesia was significantly longer in Group B (345.4 ± 38.17 min) compared to Group A (258.83 ± 20.43 min; p < 0.05). VAS scores and analgesic consumption were significantly lower in Group B during the first 6 h post-operatively. Minor side-effects (nausea, vomiting) were comparable between groups. Conclusion: Intraperitoneal and port-site infiltration of dexmedetomidine with bupivacaine provides superior, prolonged, and safe postoperative analgesia compared to bupivacaine alone in laparoscopic cholecystectomy.

Keywords: Dexmedetomidine, Bupivacaine, Intraperitoneal Analgesia, Laparoscopic Cholecystectomy, Postoperative Pain

How to Cite?: Dr. Amit Kumar Suman, Dr. Neeraj, "Analgesic Effect of Dexmedetomidine with Bupivacaine and Bupivacaine Alone in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective Randomized Double-Blinded Comparative Clinical Study", Volume 14 Issue 11, November 2025, International Journal of Science and Research (IJSR), Pages: 980-982, https://www.ijsr.net/getabstract.php?paperid=SR251112144020, DOI: https://dx.doi.org/10.21275/SR251112144020