Which microRNAs Regulate Neuroplasticity Genes During Chronic Stress and Recovery?

Trisha Shah

Abstract: Learning and stress recovery depend on neuroplasticity, the brain's capacity to adapt through modifications in neural pathways. This study explores the regulation of genes involved in neuroplasticity during chronic stress and recovery by non-coding RNAs, specifically microRNAs (miRNAs). The study uses bioinformatics tools like DESeq2, TargetScan, and Cytoscape to analyse RNA-sequencing data and predict miRNA-mRNA interactions, with a focus on important genes like BDNF, NTRK2, and CREB1. The goal of the research is to pinpoint particular miRNAs that affect neuronal adaptation and comprehend how these molecular regulators support the brain's ability to withstand stress.

Keywords: neuroplasticity, chronic stress, microRNA, gene regulation, bioinformatic analysis, hippocampus, neuronal recovery, BDNF

How to Cite?: Trisha Shah, "Which microRNAs Regulate Neuroplasticity Genes During Chronic Stress and Recovery?", Volume 14 Issue 10, October 2025, International Journal of Science and Research (IJSR), Pages: 1367-1370, https://www.ijsr.net/getabstract.php?paperid=SR251025174419, DOI: https://dx.doi.org/10.21275/SR251025174419