Bioactive Evaluations of Acetaminophen Tethered Silver Nanoparticles to Control Vector Borne Disease Mosquitoes

King Solomon Ebenezer, Rekha Manivanan, Ravikumar Sundaram, Boomi Pandi

Abstract: Acetaminophen is a non-steroidal anti-inflammatory drug that is commonly used as an analgesic and antipyretic. Due to the occurrence of side effects in human organs, several misconceptions have recently been developed about drug mechanism/toxicity. To overcome the toxicity and to increase efficacy nanotechnology is employed in the present study. Silver nanoparticles (AgNPs) were synthesized through acetaminophen drug and characterized. UV-Vis and XRD spectra provide SPR peak at 438nm and 10nm crystalline size respectively which was calculated by using intense Ag peak of 2?=38.4, 46.3, 64.7 and 78.0?. HR-SEM and HR-TEM images showed that the AgNPs have spherical morphology with 10 nm. Biological activity was carried out with bacterial pathogens and mosquito vector and showed consistent activity. In drug releasing study, AgNPs has excellent drug releasing behavior at pH-5.0 and pH-7.4. Further in vivo studies are in progress for the development of drug for the control of human diseases.

Keywords: Acetaminophen, AgNPs, drug discovery, mosquito vector, pathogens

How to Cite?: King Solomon Ebenezer, Rekha Manivanan, Ravikumar Sundaram, Boomi Pandi, "Bioactive Evaluations of Acetaminophen Tethered Silver Nanoparticles to Control Vector Borne Disease Mosquitoes", Volume 14 Issue 10, October 2025, International Journal of Science and Research (IJSR), Pages: 1470-1474, https://www.ijsr.net/getabstract.php?paperid=SR251025160605, DOI: https://dx.doi.org/10.21275/SR251025160605