Chitosan as a Bioactive Agent for Enhancing Coronal and Radicular Dentin Interfaces

Nikolova N, Todorova R.

Abstract: Chitosan, a naturally derived biopolymer, has gained attention in adhesive and endodontic dentistry for its bioactive, antimicrobial, and chelating properties. This review evaluates its role in dentin conditioning and root canal therapies, emphasizing its ability to enhance smear layer removal, promote collagen stability, and support hybrid layer formation. Chitosan?s antimicrobial action and compatibility with dental materials make it a promising adjunct in adhesive systems and intracanal applications. Despite encouraging laboratory evidence, further research is needed to standardize formulations and validate long-term clinical efficacy. The integration of chitosan offers a biologically driven approach to improve restorative and endodontic outcomes.

Keywords: chitosan, dentin bonding, hybrid layer, endodontic therapy, antimicrobial agent

How to Cite?: Nikolova N, Todorova R., "Chitosan as a Bioactive Agent for Enhancing Coronal and Radicular Dentin Interfaces", Volume 14 Issue 10, October 2025, International Journal of Science and Research (IJSR), Pages: 1129-1135, https://www.ijsr.net/getabstract.php?paperid=SR251021172917, DOI: https://dx.doi.org/10.21275/SR251021172917