Primary Bladder Lymphoma in an Elderly Asian Female: A Rare Case of Diffuse Large B-Cell Lymphoma

Ogunfusika Oluseyi Harold

Abstract: In the United Kingdom, Bladder cancer is the seventh most diagnosed cancer in the male population. Bladder cancer remains one of the most- costly cancers to treat to date and continues to be a profoundly significant contributor to cancer-related mortality rates within the United Kingdom, with an alarming statistic indicating that approximately 5,600 individuals succumb to it each year, which constitutes a striking 3% of the total number of deaths attributable to various forms of cancer. While it is widely acknowledged within the realm of oncological pathology that Transitional Cell Carcinoma represents the predominant histological variant of bladder cancer, accounting for an impressive percentage that exceeds 90% of all diagnosed cases, it is with great scholarly interest that we present a rather uncommon and exceptional case involving primary lymphoma of the bladder, which was diagnosed in an elderly female patient of Asian origin. Primary bladder lymphoma is a rare urological malignancy that is often frequently misdiagnosed due to presentation with nonspecific lower urinary tract symptoms, since it was first described in 1885 by Eve and Chaffey, it remains a rare cancer with fewer than 150 cases documented in existing literature. This academic report comprehensively outlines a case study related to a manifestation of diffuse large B Cell lymphoma in an elderly female patient. It is imperative to recognize that numerous management strategies are accessible including, but not confined to, surgical intervention, radiotherapeutic approaches, and various chemotherapeutic regimens. It is essential to emphasize that these treatment modalities may be implemented as standalone therapies or in synergistic combinations. In the specific instance of our patient, she underwent surgery (Transurethral Resection of Bladder Tumour, TURBT, which was subsequently followed by an extensive chemotherapy regimen - RCHOP. For our patient, it is significant to highlight that the follow-up included clinical evaluations, annual PET CT scans, which has revealed no metastasis after 3 years, thereby affirming that the patient is currently in a state of remission. Additionally, our review also incorporates a thorough literature analysis that clarifies the current management modalities and explore future possibilities.

Keywords: Haematuria, Primary bladder lymphoma, Diffuse large B cell lymphoma, RCHOP chemotherapy, Urological malignancy

How to Cite?: Ogunfusika Oluseyi Harold, "Primary Bladder Lymphoma in an Elderly Asian Female: A Rare Case of Diffuse Large B-Cell Lymphoma", Volume 14 Issue 10, October 2025, International Journal of Science and Research (IJSR), Pages: 959-964, https://www.ijsr.net/getabstract.php?paperid=SR251012004638, DOI: https://dx.doi.org/10.21275/SR251012004638