Clinical Profile and Surgical Outcomes of Pituitary Adenoma Patients Treated via Endoscopic Transsphenoidal Approach: Experience from a Tertiary Care Center

Dr. Baibhav Kumar, Dr. Sunil Garg

Abstract: Introduction: Pituitary adenomas are common sellar and suprasellar tumors, accounting for 10?15% of all intracranial neoplasms. The endoscopic transsphenoidal approach has become the preferred surgical method due to better visualization, minimal invasiveness, and reduced morbidity. Aim: To evaluate the clinical profile, surgical outcomes, and postoperative complications in patients with pituitary adenoma operated via the endoscopic transsphenoidal route at our institution. Materials and Methods: A retrospective analysis was conducted on 50 consecutive patients with pituitary adenoma who underwent endoscopic transsphenoidal surgery between January 2023 and August 2025 at Dr. S.N. Medical College, Jodhpur. Demographic data, hormonal profile, visual outcome, extent of resection, and postoperative complications were recorded and analyzed. Results: The mean age of patients was 43.6 years (range: 18?70 years); 32 were males and 18 females. Non-functioning adenomas constituted 60% (n=30), and functioning adenomas 40% (n=20), including prolactinomas (n=10), GH-secreting (n=6), and ACTH-secreting (n=4). Visual improvement was noted in 78% of patients with preoperative visual deficit. Gross total resection was achieved in 84% of cases. Postoperative diabetes insipidus occurred in 10% (transient in 8%, permanent in 2%). CSF leak occurred in 6% of patients and meningitis in 2%. There was no operative mortality. Hormonal normalization was achieved in 70% of functioning adenomas. Conclusion: The endoscopic transsphenoidal approach provides excellent visualization and outcomes in pituitary adenoma surgery with acceptable morbidity. It should be considered the standard approach in experienced centers.

Keywords: Pituitary adenoma, Endoscopic transsphenoidal surgery, Visual outcome, Hormonal remission, Complications

How to Cite?: Dr. Baibhav Kumar, Dr. Sunil Garg, "Clinical Profile and Surgical Outcomes of Pituitary Adenoma Patients Treated via Endoscopic Transsphenoidal Approach: Experience from a Tertiary Care Center", Volume 14 Issue 10, October 2025, International Journal of Science and Research (IJSR), Pages: 474-475, https://www.ijsr.net/getabstract.php?paperid=SR251006214200, DOI: https://dx.doi.org/10.21275/SR251006214200