International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064




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Research Paper | Zoology | India | Volume 13 Issue 6, June 2024 | Rating: 4.5 / 10


Evaluation of Antioxidant Role of Trigonella Foenum Graecum in Alloxan Induced Diabetic Wistar Albino Rats

E. Kavitha [2] | Dr. M. Sendhilvadivu [5]


Abstract: Diabetes mellitus is currently a serious global health concern. It has been demonstrated that diabetes mellitus is characterised by elevated lipid peroxidation. Oxidative stress results in increased production of ROS. This research work was undertaken to evaluate the antioxidative potential of Trigonella foenum - graecum in diabetic rats. Trigonella foenum - graecum is commonly known as Fenugreek. Diabetes was induced by an intraperitoneal injection of 150 mg/kg body weight of alloxan monohydrate dissolved in 0.9% normal saline. Alloxan is used to induce type 1 diabetes in Wistar albino rats. Alloxan is a toxic chemical substance that particularly destroys the ? - cells of the islets of Langerhans in the pancreas. Diabetic rats were treated with an aqueous extract of Trigonella foenum - graecum by oral gavage for 21 days. Hyperglycemia, an inherent feature of diabetes mellitus, lowers antioxidant defense and, as a result, promotes the development of oxidative stress. The diabetic rat produced a significant increase in lipid peroxidation (TBARS) levels in blood and kidney, indicating an increase in the generation of free radicals, and the antioxidant enzymes glutathione s - transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) were observed to be reduced in the diabetic group as compared to the control group. Diabetic rats treated with an aqueous extract of Trigonella foenum - graecum showed a decrease in TBARS levels and increased the levels of antioxidant enzymes in the blood and kidney. According to the results of this investigation, fenugreek decreases the generation of reactive oxygen species in diabetic rats and increases scavenging enzymatic activity.


Keywords: Alloxan, antioxidant effect, Wistar albino rats, Fenugreek


Edition: Volume 13 Issue 6, June 2024,


Pages: 1846 - 1851



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