Comparative Analysis of Adenosine Deaminase Level in Newly Diagnosed HIV - Positive Patients Before and After One Year of Antiretroviral Therapy

Priyanka, Dr. R. K. Vyas, Dr. B. L. Meena, Dr. Dharam Veer Sihag

Abstract: Adenosine Deaminase ADA, an inflammatory biomarker, is crucial in the immune response associated with HIV infection. This study aims to compare ADA levels in newly diagnosed HIV - positive patients before and after one year of Antiretroviral Therapy ART, and with healthy controls. Conducted at Sardar Patel Medical College, Bikaner, the observational case - control study included 50 HIV - positive patients and 50 healthy individuals. ADA levels were significantly higher in HIV - positive patients before ART compared to post - therapy and controls p - value <0.0001. The study also found a fair to substantial agreement between ADA levels and CD4 counts, with Kappa values of 0.392 and 0.766 in HIV+ patients before and after 1 - year ART. These findings suggest ADA as a potential marker for monitoring HIV progression and the efficacy of ART. The significance of this study lies in its potential to enhance the understanding of ADA as a biomarker for inflammation and immune activation in HIV - positive patients. It provides insights into the efficacy of ART in reducing ADA levels and improving immune response, thus offering a valuable tool for monitoring disease progression and treatment outcomes.

Keywords: Adenosine Deaminase, Inflammatory Biomarker, HIV, Antiretroviral therapy, Kappa Coefficient

How to Cite?: Priyanka, Dr. R. K. Vyas, Dr. B. L. Meena, Dr. Dharam Veer Sihag, "Comparative Analysis of Adenosine Deaminase Level in Newly Diagnosed HIV - Positive Patients Before and After One Year of Antiretroviral Therapy", Volume 13 Issue 6, June 2024, International Journal of Science and Research (IJSR), Pages: 1634-1639, https://www.ijsr.net/getabstract.php?paperid=SR24622094304, DOI: https://dx.doi.org/10.21275/SR24622094304