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Research Paper | Surgery | India | Volume 13 Issue 3, March 2024
Correlation Analysis of C - Reactive Protein as a Prognostic Indicator in Burns
Dr. Saurabh Singh | Dr. Anand Gautam | Dr. Harishankar Singh | Dr. Arun Bhatnagar | Dr. Ashish Luthra | Dr. Saurabh Singh
Abstract: Background: The assessment of mortality risk in burn patients aids in the development of a management protocol that improves prognosis. This study aims to determine that serum level CRP is a prognostic indicator in burns. Method: This study is a observational prospective study, conducted from July 1, 2023, to September 31, 2023, consisted of 55 patients. From the day 1 and then alternate - day serum CRP levels of all the patients included in the study were measured during their hospital stay. Patients were classified into two groups: nonsurvivors and survivors (discharged). The values and trend of change in of serum CRP were compared in both the groups. The factors that affect mortality in this study are alternate - day serum CRP level, age, TBSA, and hospital stay. Result: In our study, it was found out that CRP were significantly higher in critical burn patients. This parameter is also used to predict infection, sepsis, and ICU mortality, but there has been little research into their use in burn mortality, particularly in Indian scenarios [8]. According to the detection of serum - related cytokines, patients with sepsis after burns had more severe inflammatory responses than those without sepsis, which was reflected in the results that contents of serum CRP rose remarkably. Conclusion: In patients with burn injuries, rising trends of serum CRP values are associated with poor prognosis. Any value of serum CRP > 90 mg/L during hospitalization indicates poor prognosis with sensitivity 100% and specificity of 80.56% and 83.33%, respectively, and the likelihood of death increasing by 4.5 and 23.6 times, respectively. The trend of change in serum values of CRP can be used for prognostication of mortality and patient's response to treatment.
Keywords: CRP, Burn patients, Sepsis
Edition: Volume 13 Issue 3, March 2024,
Pages: 1607 - 1611