International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Review Papers | Dentistry | India | Volume 13 Issue 3, March 2024


Biomimetic Agents: Novel Approach to White Spot Lesions - Review

Seemadevi T | Naganandini S | Sukanya Bharadwaj


Abstract: Biomimetic remineralizing agents are compounds that replicate natural mineralization processes by emulating the bio mineralization mechanism. These active agents trigger remineralization by constructing three-dimensional structures resembling the extracellular matrix of teeth. Due to inadequate oral hygiene maintenance, white spot lesions (WSL) develop as subsurface porosities in enamel due to the demineralization process caused by caries. Clinically, they manifest as milky-white opacities on smooth surfaces. If not addressed, White Spot Lesions (WSLs) can advance to cavities and may also give rise to aesthetic concerns. Treating advanced caries requires more cost-effective prevention methods than surgical interventions. Contemporary dentistry aims to non-invasively manage white lesions through remineralization, with the goal of halting disease progression and enhancing the strength, appearance, and functionality of teeth. Various strategies exist to manage and prevent the advancement of white spot lesions, including the use of fluoride and desensitizing agents. Fluorides stands as one of the most effective and widely supported preventive measures, serving as a clinically proven remineralizing agent with ample scientific literature. In regions like India, where fluorosis is prevalent and potential side effects are a concern, biomimetic materials emerge as a promising avenue for biomineralization. These materials offer an alternative to fluoride agents and can also enhance the remineralization potential of fluoride. This review provides a succinct overview of the clinical applications and mechanisms of action of biomimetic agents for enamel remineralization.


Keywords: Biomimetic, Biomineralization, Fluorosis, Fluorides, Remineralization, White Spot Lesion


Edition: Volume 13 Issue 3, March 2024,


Pages: 372 - 376


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